Tufts - Tohoku study on curcumin + piperine combination verifies Sabinsa’s research on synergistic properties - Sami-Sabinsa Group

Sami-Sabinsa Group

"The vision of a research scientist and a passionate entrepreneur takes on social and commercial expressions." This, in short, explains the genesis and growth of Sami-Sabinsa Group.

Sami-Sabinsa Group is a research-focused multinational health science company that was founded in 1991 by the late Dr. Muhammed Majeed, an internationally renowned scientist and entrepreneur in the field of evidence-based medicine. The company is a leading manufacturer of nutraceuticals and cosmeceutical ingredients, standardized herbal extracts, enzymes, probiotics, nutricosmetics, nutritional fine chemicals, and specialty chemicals.
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Sabinsa has been promoting the combination of Curcumin C3 Complex^® and BioPerine^® for more than two decades based upon research showing the synergy between the company’s proprietary curcumin and piperine ingredients. New, independent affirmation of that synergy by scientists at Jane Mayer US Department of Agriculture Human Nutrition Center for Aging at Tufts University and Tohoku University, Japan has been published in Nutrition & Metabolism (2018 15:12). The open access study, Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1β, can be read here: doi.org/10.1186/s12986-018-0250-6

Caloric Restriction (CR) is a means of modulating energy expenditure and fat metabolism. CR has been also intimately connected with longevity. Additionally, the length of telomeres, the protective end-caps on the end of chromosomes preserving the integrity of DNA, is indicative of cellular health. Shortening of telomeres points to cellular senescence and aging. Nutrients that contribute to the lengthening of telomeres are believed to possess anti-aging properties.

In an animal study on HFD (high fat diet)-fed mice extending 53 weeks, the scientists concluded that curcumin-piperine combination contributed additively to CR and this nutrients-combination has potential to enhance CR effects for the prevention of metabolic syndrome. In HFD-fed mice, administration of the curcumin-piperine combination maintained the telomere length more efficiently than the individual components, thus indicating their synergistic activity. The scientists also measured the loss of fat in the HFD-fed animals using MRI (Magnetic Resonance Imaging). This nutrients-combination was effective also in reducing certain inflammatory cytokines as measured by the levels of circulating cytokines.

“On the whole it was concluded that this nutrient combination, curcumin-piperine, works well to reduce total body fat, reduces cellular aging as indicated by preserving telomere length, and enhance the CR effects for the prevention of metabolic syndrome by reducing the low grade chronic inflammation that always persists in obese conditions,” said Nagabhushanam Kalyanam, PhD, President (R&D), Sabinsa.

What We Do

Sami-Sabinsa Group Limited (formerly Sami Labs Limited), a pioneer and global leader in health science, is a leading producer of nutraceuticals, cosmeceuticals, standardized herbal extracts, fine chemicals, specialty chemicals, probiotics, and enzymes.

The company’s corporate R&D encompasses independent research divisions, including Natural Drugs, Phytochemistry, Synthetic Chemistry, Tissue Culture, Biotechnology, Analytical R&D, Biological Research, Microbiology, and Formulation R&D. These divisions collaborate in a synergistic work model to produce products that adhere to international standards.

With the collective wisdom of over 120 research scientists, Sami-Sabinsa Group has developed standardized natural extracts that render alternative therapy to emerging nutritional and health requirements across the globe.